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It is used to lighten and even out skin tones, as well as to reduce the appearance of scars and stretch marks, while also nourishing the skin beneath the surface

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A limited number of studies have reported increased systemic levels of claudins as a marker for impaired intestinal barrier function, e.g., increased serum claudin-5 in children with attention deficit hyperactivity disorder (67) and increased urinary claudin-3 in patients with active Crohn's disease which was associated with decreased claudin-3 staining in intestinal biopsies (68)